Estudo COMMODORE: Um estudo de acompanhamento de longo prazo de gefitinibe versus quimioterapia de resgate em leucemia mieloide aguda recidivada/refratária com mutação FLT3 – aml-hub.com
O estudo COMMODORE: um estudo de acompanhamento de longo prazo de gefitinibe versus quimioterapi…
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During the European Hematology Association (EHA) 2025 Congress, Jianxiang Wang presented the long-term follow-up data from the phase III COMMODORE trial of gilteritinib vs salvage chemotherapy in predominantly Asian patients with R/R FLT3m AML.
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盧修斯 吉瑞替尼 Gilteritinib 線上購買
吉瑞替尼是一種於2018年11月在美國核准上市的處方藥，標靶FMS樣酪胺酸激酶3（FLT3）及其突變（包括FLT3-ITD及FLT3-TKD如D835Y、I836等），使用時需謹遵醫囑。
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吉瑞替尼片 GILLIDX Gilteritinib 40mg
吉列替尼是一種有效、選擇性、口服FMS樣酪胺酸激酶3（FLT3）抑制劑。吉瑞替尼的核准是基於一項全球多中心開放性隨機對照的III期臨床試驗ADMIRAL研究，該研究最終納入371例血液或骨髓檢測到FLT3突變的複發或難治性AML患者，並以2:1比例隨機分配，分別接受吉瑞替尼或挽救性化療。 ADMIRAL研究的主要複合終點為總存活期（OS）和伴隨完全或部分血液學恢復的完全緩解（CR/CRh）率。這項研究結果發表在權威醫學期刊《新英格蘭醫學雜誌》（NEJM）。
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