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PDGFRA 18 GIST AdvSM ISM
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PDGFRA 18 GIST AdvSM ISM
Avapritinib How It Works How It Works ，
2 (GIST) PDGFRA 18 AYVAKIT (2.2) (GIST) 300 mg (2.2) (AdvSM) 200 mg (2.3) (ISM) 25 mg (2.4) Child-Pugh C AYVAKIT (2.7) 2.1 AYVAKIT， 1 2 [ (12.3)]
5 Precautions (2.5, 5.1) AYVAKIT GIST AdvSM ISM ， ， AYVAKIT， ， ， (2.5, 5.2) (5.3) -
11 Description ， (S)-1-(4- )-1-(2-(4-(6-(1- -1H- -4- ) [2,1-f][1,2,4] -4- ) - ) -5- ) -1- C26H27FN10， 498.57 g/mol 0.1N HCl pH 1.0 pH 2.5 4.0 7.0 25℃ 3.6 mg/mL 0.14 mg/mL 0.07 mg/mL 0.07 mg/mL
PDGFRA 18 GIST AdvSM ISM
2 (GIST) PDGFRA 18 AYVAKIT (2.2) (GIST) 300 mg (2.2) (AdvSM) 200 mg (2.3) (ISM) 25 mg (2.4) Child-Pugh C AYVAKIT (2.7) 2.1 AYVAKIT， 1 2 [ (12.3)]
5 Precautions (2.5, 5.1) AYVAKIT GIST AdvSM ISM ， ， AYVAKIT， ， ， (2.5, 5.2) (5.3) -
8.1 How It Works[ (12.1)]，AYVAKIT AYVAKIT ， ， 31.4 6.3 2.7 25 mg 200 mg 300 mg AUC ， ，
12 12.1 How It Works ， KIT D816V PDGFRA PDGFRA D842 KIT 11 11/17 17 ， IC50 25 nM PDGFRA KIT ， KIT PDGFRB CSFR1 ， KIT D816V ，IC50 4 nM， KIT 48 ， KIT ，
14 14.1 AYVAKIT NAVIGATOR (NCT02508532) ， (GIST)， ECOG (PS) 0 2 AYVAKIT 300 mg 400 mg 1.33 ， 400 mg ， 300 mg 300 mg 400 mg (ORR) ，
Indications
PDGFRA 18 GIST AdvSM ISM
How It Works
Avapritinib How It Works How It Works ，
Dosage
2 (GIST) PDGFRA 18 AYVAKIT (2.2) (GIST) 300 mg (2.2) (AdvSM) 200 mg (2.3) (ISM) 25 mg (2.4) Child-Pugh C AYVAKIT (2.7) 2.1 AYVAKIT， 1 2 [ (12.3)]
Precautions
5 Precautions (2.5, 5.1) AYVAKIT GIST AdvSM ISM ， ， AYVAKIT， ， ， (2.5, 5.2) (5.3) -
