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Gefitinib was first approved by the U.S. FDA in 2015 for the treatment of patients with non-small cell lung cancer with specific EGFR mutations.
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Multiple clinical trials have demonstrated that dacomitinib has the potential to prolong progression-free survival (PFS) and overall survival (OS) compared to other EGFR-TKIs. For example, in the ARCHER-1050 clinical study, the median PFS and OS in the dacomitinib group were significantly better than those in the gefitinib group.
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