Eficacia de gilteritinib en comparación con alectinib para el tratamiento del cáncer de pulmón de células no pequeñas con reordenamiento de ALK – Biblioteca en línea de Wiley

Alectinib is a targeted therapy for ALK-positive non-small cell lung cancer, with clearly defined indications and dosages. During use, attention should be paid to potential side effects, and it should be used rationally under the guidance of a doctor.

Alectinib is a targeted therapy that blocks the activity of ALK (anaplastic lymphoma kinase) and is used to treat ALK-positive non-small cell lung cancer (NSCLC) and anaplastic large cell lymphoma (ALCL).

Gefitinib is a prescription drug approved for marketing in the United States in November 2018. It targets FMS-like tyrosine kinase 3 (FLT3) and its mutations (including FLT3-ITD and FLT3-TKD such as D835Y, I836, etc.). It should be used in strict accordance with the doctor's instructions.

Gipritinib is a potent, selective, oral FMS-like tyrosine kinase 3 (FLT3) inhibitor. The approval of gipritinib was based on the global, multicenter, open-label, randomized, controlled phase III clinical trial ADMIRAL, which ultimately enrolled 371 patients with relapsed or refractory AML who had FLT3 mutations detected in their blood or bone marrow. These patients were randomized 2:1 to receive either gipritinib or salvage chemotherapy. The primary composite endpoint of the ADMIRAL study was overall survival (OS) and the rate of complete remission (CR/CRh) with complete or partial hematologic recovery. The results of this study were published in the prestigious medical journal *The New England Journal of Medicine* (NEJM).