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Dari empat pasien dengan adenokarsinoma paru-paru mutasi NF1 stadium lanjut dengan status performa yang buruk, hanya satu yang mencapai stabilitas penyakit setelah pengobatan trametinib lini ketiga, yang mungkin terkait dengan mutasi alel. Pemeriksaan gen MAPK yang lebih luas diperlukan. – MedSci

体能状态差的4例NF1突变晚期肺腺癌三线曲美替尼治疗仅1例疾病稳定,或与一个等位基因突变等有关,后续需扩大MAPK基因筛查 梅斯医学 MedSci

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