Lucius Ovisibat – Buy online

Lucius Ovisibat – Buy online

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Key Highlights

Indicated for the treatment of cholestatic pruritus in patients 3 months of age and older with progressive familial intrahepatic cholestasis (PFIC), and in patients 12 months of age and older with Alagille syndrome (ALGS).

Service Promise

Direct from JapanLicensed PharmacyPharmacist CheckedEditable in Admin

Specifications

Specification
400mcg*30 capsules
Manufacturer
Lucius Pharmaceuticals
Shipping
Hong Kong

10000 in stock

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Product Info

English Name
Odevixibat
Generic Name
Odevixibat

Specifications

Specification
400mcg*30 capsules
Manufacturer
Lucius Pharmaceuticals
Shipping
Hong Kong

Full Details

Indications

Indicated for the treatment of cholestatic pruritus in patients 3 months of age and older with progressive familial intrahepatic cholestasis (PFIC), and in patients 12 months of age and older with Alagille syndrome (ALGS).

How It Works

IBAT PFIC ALGS PFIC PFIC ALGS ， IBAT ， ， [ 12.2 ]

Pharmacology

12.1 How It Works IBAT PFIC ALGS PFIC PFIC ALGS ， IBAT ， ， [ 12.2 ]

Dosage

2.1 3 PFIC BYLVAY 40 mcg/kg， ， 1 3 ， 40 mcg/kg ， 120 mcg/kg， 6 mg BYLVAY 19.5 kg BYLVAY 19.5 kg

Precautions

5.1 BYLVAY (DILI) PFIC ALGS ， 6 DILI ，2 ALGS PFIC ， 6 8 ， ， BYLVAY ，

Contraindications

IBAT BYLVAY ， [ Precautions 5.1 ]

Drug Interactions

7.1 ， BYLVAY 4 4 [ Dosage (2.3)] ， BYLVAY

Adverse Reactions

[ Precautions(5.1)] [ Precautions(5.2)] [ Precautions(5.3)] 6.1 ， ， PFIC 1 24 ， BYLVAY 40 mcg/kg 120 mcg/kg [ (14.1)]

Package Insert

Ingredients

11 BYLVAY BYLVAY IBAT ， (2S)-2-{[(2R)-2-(2-{[3,3- -7-( )-1,1- -5- -2,3,4,5- -1H-1λ 6 ,2,5- -8- ] } )-2-(4- ) ] } ， ， C 37 H 48 N 4 O 8 S 2 × 1.5 H 2 O， 768.0 g/mol 740.9 g/mol pH ， pH BYLVAY ， ， 200 600

Indications

Indicated for the treatment of cholestatic pruritus in patients 3 months of age and older with progressive familial intrahepatic cholestasis (PFIC), and in patients 12 months of age and older with Alagille syndrome (ALGS).

Dosage

2.1 3 PFIC BYLVAY 40 mcg/kg， ， 1 3 ， 40 mcg/kg ， 120 mcg/kg， 6 mg BYLVAY 19.5 kg BYLVAY 19.5 kg

Adverse Reactions

[ Precautions(5.1)] [ Precautions(5.2)] [ Precautions(5.3)] 6.1 ， ， PFIC 1 24 ， BYLVAY 40 mcg/kg 120 mcg/kg [ (14.1)]

Contraindications

IBAT BYLVAY ， [ Precautions 5.1 ]

Precautions

5.1 BYLVAY (DILI) PFIC ALGS ， 6 DILI ，2 ALGS PFIC ， 6 8 ， ， BYLVAY ，

Use in Pregnancy and Lactation

8.1 BYLVAY ， ，BYLVAY ， odevixibat ， 2.1

Drug Interactions

7.1 ， BYLVAY 4 4 [ Dosage (2.3)] ， BYLVAY

Clinical Pharmacology

12 12.1 How It Works (IBAT) (PFIC) (ALGS) PFIC PFIC ALGS ， IBAT ， ， [ (12.2)] 12.2 PFIC ALGS

Pharmacology and Toxicology

13 13.1 2 ， 100 mg/kg/ odevixibat ， AUC 231 459 Ames 1000 mg/kg/

Clinical Studies

14 14.1 PFIC BYLVAY 1 (NCT03566238) ， 24 1 62 6 17 ， PFIC 1 2 ， 1 ， ABCB11 BSEP INR 1.4 ALT ULN 10 n=20 40 mcg/kg n=23 120 mcg/kg n=19

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Description

Indications

Indicated for the treatment of cholestatic pruritus in patients 3 months of age and older with progressive familial intrahepatic cholestasis (PFIC), and in patients 12 months of age and older with Alagille syndrome (ALGS).

How It Works

IBAT PFIC ALGS PFIC PFIC ALGS ， IBAT ， ， [ 12.2 ]

Pharmacology

12.1 How It Works IBAT PFIC ALGS PFIC PFIC ALGS ， IBAT ， ， [ 12.2 ]

Dosage

2.1 3 PFIC BYLVAY 40 mcg/kg， ， 1 3 ， 40 mcg/kg ， 120 mcg/kg， 6 mg BYLVAY 19.5 kg BYLVAY 19.5 kg

Precautions

5.1 BYLVAY (DILI) PFIC ALGS ， 6 DILI ，2 ALGS PFIC ， 6 8 ， ， BYLVAY ，

Contraindications

IBAT BYLVAY ， [ Precautions 5.1 ]

Drug Interactions

7.1 ， BYLVAY 4 4 [ Dosage (2.3)] ， BYLVAY

Adverse Reactions

[ Precautions(5.1)] [ Precautions(5.2)] [ Precautions(5.3)] 6.1 ， ， PFIC 1 24 ， BYLVAY 40 mcg/kg 120 mcg/kg [ (14.1)]