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2021 10 29 (FDA) ， BCR-ABL1 T315I ，
10000 in stock
(CP) (Ph+ CML)
Asciminib How It Works How It Works ，
2 Ph+ Recommended dosage: 80 mg， 40 mg (2.1) T315I Ph+ Recommended dosage: 200 mg (2.2) SCEMBLIX 2 1 (2.5) ， (2.5) 2.1 Ph+ SCEMBLIX 80 mg， 40 mg， 12
11 SCEMBLIX N-[4-( ) ]-6-[(3R)-3- -1- ]-5-(1H- -3- ) -3- (1/1) C₂₀H₁₈ClF₂N₅O₃·HCl， 486.30 g/mol， 449.84 g/mol SCEMBLIX ， ， 20 40 100 21.62 43.24 108.10
(CP) (Ph+ CML)
2 Ph+ Recommended dosage: 80 mg， 40 mg (2.1) T315I Ph+ Recommended dosage: 200 mg (2.2) SCEMBLIX 2 1 (2.5) ， (2.5) 2.1 Ph+ SCEMBLIX 80 mg， 40 mg， 12
8.1 How It Works，SCEMBLIX [ (12.1)] SCEMBLIX ， ， asciminib ，
12 12.1 How It Works Asciminib ABL/BCR-ABL1 Asciminib ABL ， BCR::ABL1 ABL1 (CML) ，asciminib BCR::ABL1 T315I 12.2 - 10 mg 200 mg asciminib 80 mg 0.25 5 ， BCR::ABL1 24 MMR 10 mg 280 mg asciminib 80 mg 0.25 7 ， ，
13 13.1 2 ， 20 66 200 mg/kg/ asciminib， 10 30 66 mg/kg/ asciminib ， 66 mg/kg asciminib AUC 40 mg 80 mg 8 6 ， 200 mg Ames ，Asciminib
14 14.1 Ph+ (Ph+ CML-CP) ASC4FIRST (NCT04971226) ， SCEMBLIX Ph+ (Ph+ CML-CP) ， 405 1:1 ， SCEMBLIX (IS-TKI) ， ， TKI ， EUTOS (ELTS) ， TKI TKI，
Indications
(CP) (Ph+ CML)
How It Works
Asciminib How It Works How It Works ，
Dosage
2 Ph+ Recommended dosage: 80 mg， 40 mg (2.1) T315I Ph+ Recommended dosage: 200 mg (2.2) SCEMBLIX 2 1 (2.5) ， (2.5) 2.1 Ph+ SCEMBLIX 80 mg， 40 mg， 12
