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Keunggulan Produk

PDGFR-α/β FGFR1-3 VEGFR1-3 CSF1R FLT-3 , 2014 10 IPF ,

Jaminan Layanan

Pengiriman Lintas NegaraApotek ResmiDitinjau ApotekerJaminan Keaslian

Spesifikasi

Spesifikasi
100mg*60 150mg*60
Produsen
Lucius Pharmaceuticals
Pengiriman
Hong Kong
SKU: N/A Kategori: , Tag: Brand:

Informasi Produk

Nama Inggris
Nintedanib
Nama Generik
Nintedanib

Spesifikasi

Spesifikasi
100mg*60 150mg*60
Produsen
Lucius Pharmaceuticals
Pengiriman
Hong Kong

Rincian Lengkap

Indikasi

Used to treat idiopathic pulmonary fibrosis (IPF) in adults, chronic fibrosing interstitial lung disease (ILD) with a progressive phenotype in adults, and to slow the decline of lung function in adults with systemic sclerosis-associated interstitial lung disease (SSc-ILD).

Mekanisme Kerja

, RTK nRTK RTK PDGFR α β FGFR 1 3 VEGFR 1 3 1 CSF1R Fms -3 FLT-3 FLT-3 , ILD ATP , , ILD

Farmakologi

12.1 Mekanisme Kerja , (RTK) (nRTK) RTK (PDGFR) α β (FGFR) 1 3 (VEGFR) 1 3 1 (CSF1R) Fms -3 (FLT-3) FLT-3 , (ILD) (ATP) ,

Peringatan

5.1 Child-Pugh B Child-Pugh C [ (8.6) (12.3)] Child-Pugh A [ Dosis dan Penggunaan (2.3)] 5.2 DILI , DILI

Interaksi Obat

7.1 P- (P-gp) CYP3A4 P-gp , CYP3A4 [ (12.3)] P-gp CYP3A4 , 60% P-gp CYP3A4 [ (12.3)] ,

Efek Samping

[ Peringatan(5.2)] [ Peringatan(5.3)] - [ Peringatan(5.4)] [ Peringatan(5.5)] [ Peringatan(5.6)] [ Peringatan(5.7)] [ Peringatan(5.8)] 6.1 ,

Package Insert

Ingredients

11 , [ Mekanisme Kerja(12.1)] , 1H- -6- ,2,3- -3-[[[4-[ [(4- -1- ) ] ] ] ] ]-2- -, ,(3Z)-, (1:1) , C31H33N5O4ꞏC2H6O3S, 649.76 g/mol , 100 150 120.40 180.60 Medi

Indications

Used to treat idiopathic pulmonary fibrosis (IPF) in adults, chronic fibrosing interstitial lung disease (ILD) with a progressive phenotype in adults, and to slow the decline of lung function in adults with systemic sclerosis-associated interstitial lung disease (SSc-ILD).

Efek Samping

[ Peringatan(5.2)] [ Peringatan(5.3)] - [ Peringatan(5.4)] [ Peringatan(5.5)] [ Peringatan(5.6)] [ Peringatan(5.7)] [ Peringatan(5.8)] 6.1 ,

Precautions

5.1 Child-Pugh B Child-Pugh C [ (8.6) (12.3)] Child-Pugh A [ Dosis dan Penggunaan (2.3)] 5.2 DILI , DILI

Interaksi Obat

7.1 P- (P-gp) CYP3A4 P-gp , CYP3A4 [ (12.3)] P-gp CYP3A4 , 60% P-gp CYP3A4 [ (12.3)] ,

Clinical Pharmacology

12 12.1 Mekanisme Kerja , (RTK) (nRTK) RTK (PDGFR) α β (FGFR) 1-3 (VEGFR) 1-3 1 (CSF1R) Fms -3 (FLT-3) FLT-3 , (ILD) ATP , , ILD nRTK Lck Lyn

Pharmacology and Toxicology

13 13.1 10 30 mg/kg/ MRHD AUC 4 , MRHD AUC, 100 mg/kg/ 3 ,

Clinical Studies

14 14.1 II 1 [NCT00514683] III 2 [NCT01335464] 3 [NCT01335477] 1231 (IPF) , , 150 mg 52 2 3 1 3:2 1 1:1 150 mg , 52

Ulasan Produk (14)

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Deskripsi produk

Indikasi

Used to treat idiopathic pulmonary fibrosis (IPF) in adults, chronic fibrosing interstitial lung disease (ILD) with a progressive phenotype in adults, and to slow the decline of lung function in adults with systemic sclerosis-associated interstitial lung disease (SSc-ILD).

Mekanisme Kerja

, RTK nRTK RTK PDGFR α β FGFR 1 3 VEGFR 1 3 1 CSF1R Fms -3 FLT-3 FLT-3 , ILD ATP , , ILD

Farmakologi

12.1 Mekanisme Kerja , (RTK) (nRTK) RTK (PDGFR) α β (FGFR) 1 3 (VEGFR) 1 3 1 (CSF1R) Fms -3 (FLT-3) FLT-3 , (ILD) (ATP) ,

Peringatan

5.1 Child-Pugh B Child-Pugh C [ (8.6) (12.3)] Child-Pugh A [ Dosis dan Penggunaan (2.3)] 5.2 DILI , DILI

Interaksi Obat

7.1 P- (P-gp) CYP3A4 P-gp , CYP3A4 [ (12.3)] P-gp CYP3A4 , 60% P-gp CYP3A4 [ (12.3)] ,

Efek Samping

[ Peringatan(5.2)] [ Peringatan(5.3)] - [ Peringatan(5.4)] [ Peringatan(5.5)] [ Peringatan(5.6)] [ Peringatan(5.7)] [ Peringatan(5.8)] 6.1 ,

Informasi tambahan

Specification

100mg*60粒, 150mg*60粒