L’inhibiteur de BRAF de Pierfaber, l’« encofénib », a été soumis à une demande d’autorisation de mise sur le marché – ByDrug
恩考芬尼是一款BRAF抑制剂，靶向BRAF V600E，以及野生型BRAF和CRAF。BRAF是一种丝氨酸/苏氨酸蛋白激酶，与ARAF和CRAF同属RAF激酶家族，参与RAS-RAF-MEK-ERK信号通路。多种恶性肿瘤中都发现BRAF突变，包括黑色素瘤、结直肠癌、非小细胞肺癌和甲状腺癌等，其中BRAF V600E是最常见的突变类型。在体外实验中，恩考芬尼对…
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